Descended from the ancient Uto-Azteca tribe of Mexico, the ancestors of the Pascua Yaqui Tribe first settled in the United States near Nogales and South Tucson. In the late 19th century, the tribe began to expand into settlements north of Tucson in an area they named Pascua Village, and in the city of Guadalupe near Tempe.
The Pascua Yaqui Tribe of Yaqui Native Americans was recognized by the United States government in 1978. This recognition gave the tribe powers of self-government, with Reservation status for Yaqui lands, and provided all federal services and benefits, including those by the Bureau of Indian Affairs and the Indian Health Service. In 1988, the Tribe's first constitution was approved, and the tribe received designation as a historical tribe in 1994.